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SMART Symposium on Conquering the Challenges of ALS and Related Neuromuscular Diseases
SMART
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Date
October 28-31, 2025
Registration Deadline
October 24, 2025
Venue
Cloud Park International Conference Center, Shenzhen, China
About
Organizers
Confirmed Speakers
Program
Registration
Call for Abstracts
Short Talk Presentation
Poster Session
Accommodation
Contact Us
About
Neuromuscular diseases such as ALS present a global challenge to human health and medicine. Every year, millions suffer from these diseases, and there is still no effective treatment. Emerging efforts from cross-field collaborations led to significant progress toward FDA-approved therapeutics, such as ASO therapies. Our symposium aims to bring together academic, clinical, and industrial experts in ALS and other neuromuscular diseases. Through their brainstorming, we seek to identify ways to conquer the major challenges of these devastating diseases.
Organizers
Xiaojiang LI, Jinan University
Ke ZHANG, Shenzhen Bay Laboratory
Aaron D. GITLERStanford University
Shuying SUNJohns Hopkins School of Medicine
Confirmed Speakers

Keynote Speakers

(in alphabetic order)

C. Frank BENNETT, Ionis Pharmaceuticals, Inc.

Don W. CLEVELAND, University of California, San Diego

Jeffrey D. ROTHSTEIN, Johns Hopkins School of Medicine

Junying YUAN, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

 

Invited Speakers

(in alphabetic order)

Ge BAI, Zhejiang University

Gong CHEN, Jinan University

Xiangjun CHEN, Huashan Hospital, Fudan University

Yelin CHEN, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

Sandrine Da CRUZ, VIB-KU Leuven Center for Brain & Disease Research

Dongsheng FAN, Peking University Third Hospital

Fen-Biao GAO, University of Massachusetts

Yun GE, Shenzhen Bay Laboratory, Peking University Shenzhen Graduate School

Siqi HONG, Children's Hospital of Chongqing Medical University

Justin K. ICHIDA, University of Southern California

Ralf JAUCH, The University of Hong Kong

Clotilde LAGIER-TOURENNE, Massachusetts General Hospital, Harvard Medical School

Andrew Stephen LEE, Shenzhen Bay Laboratory, Peking University Shenzhen Graduate School

Chunghun LIM, Korea Advanced Institute of Science and Technology

Yi LIN, Tsinghua University, Peking-Tsinghua Joint Center for Life Sciences

Bai LU, Tsinghua University

Magdalini POLYMENIDOU, University of Zurich

Manish RAISINGHANI, Target ALS Foundation

Linhao RUAN, Huazhong University of Science and Technology

Neil A. SHNEIDER, Columbia University

Kun SUN, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Yi SUN, Shenzhen University of Advanced Technology

Christine Vande VELDE, University of Montréal

Program
October 28
October 29
October 30
October 31
Show All
Day 1
10:30-18:00

10:30-14:00

Registration

14:00-18:00

Short Talks Selected from Abstracts

Day 2
08:00-20:30

08:00-09:00

On-site Registration

09:00-09:15

Opening and Introductory Remarks

Keynote Lecture I
09:15-10:30

09:15-10:00

Jeffrey D. ROTHSTEIN, Johns Hopkins School of Medicine

TDP-43 Import: A Whole Genome CRISPRi Screen in Human Neurons Reveals Multiple ALS, FTD, and ALS Genes That Work by Altering TDP-43 Import

10:00-10:30

Group Photo & Break

Session I. ALS Cell Biology
10:30-12:10

10:30-10:55

Linhao RUAN, Huazhong University of Science and Technology

INFINITE: A Screen Platform for Neuronal Nuclear Cytoplasmic Transport Regulators

10:55-11:20

Chunghun LIM, Korea Advanced Institute of Science and Technology

Lipid Transfer Proteins at ER Membrane Contact Sites Sustain Lipid Homeostasis and Neuronal Survival in C9ORF72-Associated ALS

11:20-11:45

Sandrine DA CRUZ, VIB-KU Leuven Center for Brain & Disease Research

Uncovering Local Mechanisms of Axon/Synapse Maintenance and Demise in ALS/FTD

11:45-12:10

Magdalini POLYMENIDOU, University of Zurich

Understanding the Life Cycle of TDP-43: Aggregation Triggers & Toxicity Effectors

12:10-14:00

Lunch & Poster Session

Session II. RNA Metabolism and Stress Granules
14:00-16:05

14:00-14:25

Shuying SUN, Johns Hopkins School of Medicine

RNA Metabolism Dysfunction in C9ORF72-ALS/FTD

14:25-14:50

Clotilde LAGIER-TOURENNE, Massachusetts General Hospital, Harvard Medical School

Disruption of RNA Metabolism in Neurodegenerative Diseases and Emerging Therapeutic Strategies

14:50-15:15

Christine VANDE VELDE, University of Montréal

Stress Granules in ALS/FTD Pathogenesis: Friend or Foe?

15:15-15:40

Ge BAI, Zhejiang University

Stress Granules and Neurodegeneration

15:40-16:05

Ke ZHANG, Shenzhen Bay Laboratory

Novel Ways to Target Stress Granules

16:05-16:15

Break

Keynote Lecture II
16:15-17:00

16:15-17:00

Don W. CLEVELAND, University of California, San Diego
TBA

18:30-20:30

Banquet

Day 3
08:30-18:15

08:30-09:00

On-site Registration

Keynote Lecture III
09:00-09:45

09:00-09:45

Junying YUAN, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

RIPK1 and Neuroinflammation

Session III. Liquid-Liquid Phase Separation
09:45-10:35

09:45-10:10

Yi LIN, Tsinghua University, Peking-Tsinghua Joint Center for Life Sciences

Spatiotemporal Control of Biological Processes through Dynamic Phase Separation

10:10-10:35

Yun GE, Shenzhen Bay Laboratory

Target Protein Manipulation to Reveal Glycosylation Functions in Condensates

10:35-10:45

Break

Session IV. Animal and iPSC models
10:45-12:25

10:45-11:10

Xiaojiang LI, Jinan University

The Pathogenesis of Cytoplasmic TDP-43

11:10-11:35

Fen-Biao GAO, University of Massachusetts
Understanding C9ORF72-ALS/FTD: Novel Insights from Drosophila and iPSC-Derived Patient Motor Neurons

11:35-12:00

Justin K. ICHIDA, University of Southern California

Identifying New Therapeutic Targets for ALS Using Rare Genetic Variants and CRISPR Technology

12:00-12:25

Ralf JAUCH, The University of Hong Kong

Direct Somatic to Neural Stem Cell Conversion to Model and Revert Age-linked Neurological Disorders

12:25-14:00

Lunch & Poster Session 

Special Lecture
14:00-14:25

14:00-14:25

Manish RAISINGHANI, Target ALS Foundation

Target ALS: Pioneering Collaboration and Innovation to Accelerate ALS Research and Drug Discovery

Session V. ALS Diagnosis and Therapeutics I
14:25-15:40

14:25-14:50

Neil A. SHNEIDER, Columbia University

Silencing FUS and Other Rare Genetic Forms of ALS

14:50-15:15

Gong CHEN, Jinan University

In Vivo Neural Regeneration and Its Potential in the Treatment of ALS

15:15-15:40

Dongsheng FAN, Peking University Third Hospital

Preliminary Study on the Treatment of ALS with rTMS under the Guidance of pBFS

15:40-15:50

Break

Session VI. ALS Diagnosis and Therapeutics II
15:50-17:30

15:50-16:15

Aaron D. GITLER, Stanford University

ALS Therapeutic Targets

16:15-16:40

Bai LU, Tsinghua University

New Strategies to Accelerate ALS Drug Development

16:40-17:05

Yi SUN, Shenzhen University of Advanced Technology
Autologous Rejuvenated Cell Therapy for ALS

17:05-17:30

Kun SUN, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Translational Advances in SMA Care: From Novel Diagnostics to Prenatal Gene Therapy in Murine Systems

Keynote Lecture IV
17:30-18:15

17:30-18:15

C. Frank BENNETT, Ionis Pharmaceuticals, Inc.

TBA

Day 4
08:30-10:50

08:30-09:00

On-site Registration

Session VII. Other Neurodegenerative Diseases
09:00-10:40

09:00-09:25

Xiangjun CHEN, Huashan Hospital, Fudan University

Oligogenic ALS Modeling Based on Genotype-phenotype Correlation from the Huashan TRC Study

09:25-09:50

Andrew Stephen LEE, Shenzhen Bay Laboratory, Peking University Shenzhen Graduate School

Clinical Translation of Extracellular Vesicle Based Gene Therapy

09:50-10:15

Siqi HONG, Children's Hospital of Chongqing Medical University

Diagnosis and Treatment of NMDs in Children: Current Status and Clinical Challenges

10:15-10:40

Yelin CHEN, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

Using ApoE C-terminal Domain to Treat Alzheimer’s Disease

10:40-10:50

Closing Remarks and Poster Award Announcement

Registration

Registration Deadline: October 24, 2025

 

Please click the Register link at the top of this web page to proceed with the registration process.

Registration will be closed when the number of applications reaches 250.

 

Registration Fees

*Please upload valid documents for review if you are a student.

 

Notice

1. When making transfers, please include the following note: ALS + [Your Full Name].

2. Please complete the registration and payment before October 24, 2025. Attendees registering on-site will be provided with only the electronic program.

3. The electronic invoice for the registration fee will be sent to the registered email address within 15 working days after the symposium.

 

Refund Policy

1. A 2% administrative fee will be charged for all refund transactions.

2. Refund requests submitted after 18:00 (GMT+8) on October 27, 2025 will not be processed.

Call for Abstracts

Abstract Submission Deadline: September 30, 2025

 

Submission Guidelines:

  • Submit an abstract when registering. Select whether you prefer to present a poster or short talk. Note: Due to limited slots of short talks, we cannot guarantee every abstract selected for short talks. So please be prepared to present a poster even if you selected "Short talk" as your preference.
  • Each presenting author can submit one abstract only.
  • Abstracts will be reviewed by the organizing committee for quality and alignment with the symposium's scope and topics. The organizing committee will also select abstracts for short talks.
  • A confirmation email will be sent to the corresponding authors of each accepted abstract.
Short Talk Presentation

In the afternoon of October 28, we will have a student/postdoc/junior scientist session featuring short talks selected from submitted abstracts. The symposium will cover the registration and accommodation fees for the short talk presenters.

Poster Session

This conference will feature poster presentation sessions, with awards for outstanding posters. We sincerely invite you to submit your topics and participate in the poster presentation (encouraging the display of the latest research advancements or unpublished research topics).

 

How to participate: Upload poster information to the registration website.

 

Poster requirements: If you will present a poster, please print it yourself and bring it to the conference venue. The staff will post it in the designated area.

 

Poster size: Width 80 cm * Height 120 cm

 

Accommodation

We do not provide centralized accommodation for this symposium. Participants can arrange their own accommodation by contacting nearby hotels. (If you encounter any difficulty in booking a hotel, please contact us at symposium@smart.org.cn.)

 

1. EVEN Hotels Shenzhen Guangming Cloud Park, an IHG Hotel

Address: No. 98 Zhenyuan Road, Guangming District, Shenzhen

The hotel is 200 meters (~3-minute walk) from the conference venue.

Contact: Mr. Zhou, Tel: +86-135 0841 8360

 

2. Holiday Inn Express Shenzhen Guangming Cloud Park, an IHG Hotel

Address: No. 98 Zhenyuan Road, Guangming District, Shenzhen

The hotel is 200 meters (~3-minute walk) from the conference venue.

Contact: Mr. Zhou, Tel: +86-135 0841 8360

 

3. SYSU Academic Vila, Shenzhen Campus

Address: No.66 Gongchang Road, Guangming District, Shenzhen, Guangdong, China, Guangming District, Shenzhen

The hotel is 2.5 kilometers (~5-minute drive) from the conference venue.

Contact: Mr. Ran, +86-133 3028 2207

 

4. Guangming CIMC Executive Apartments Hotel

Address: CIMC Executive Apartments Hotel, Qiaoming Road, Fenghuang Street, Guangming District, Shenzhen

The hotel is 7.6 kilometers (~20-minute drive) from the conference venue.

Contact: Mr. Lu, Tel: +86-138 2659 2644

Contact Us

Email: symposium@smart.org.cn

Tel: +86-173 2236 4121

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