Keynote Speakers
(in alphabetic order)
C. Frank BENNETT, Ionis Pharmaceuticals, Inc.
Don W. CLEVELAND, University of California, San Diego
Jeffrey D. ROTHSTEIN, Johns Hopkins School of Medicine
Junying YUAN, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Invited Speakers
(in alphabetic order)
Ge BAI, Zhejiang University
Gong CHEN, Jinan University
Xiangjun CHEN, Huashan Hospital, Fudan University
Yelin CHEN, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Sandrine Da CRUZ, VIB-KU Leuven Center for Brain & Disease Research
Dongsheng FAN, Peking University Third Hospital
Fen-Biao GAO, University of Massachusetts
Yun GE, Shenzhen Bay Laboratory, Peking University Shenzhen Graduate School
Siqi HONG, Children's Hospital of Chongqing Medical University
Justin K. ICHIDA, University of Southern California
Ralf JAUCH, The University of Hong Kong
Clotilde LAGIER-TOURENNE, Massachusetts General Hospital, Harvard Medical School
Andrew Stephen LEE, Shenzhen Bay Laboratory, Peking University Shenzhen Graduate School
Chunghun LIM, Korea Advanced Institute of Science and Technology
Yi LIN, Tsinghua University, Peking-Tsinghua Joint Center for Life Sciences
Bai LU, Tsinghua University
Magdalini POLYMENIDOU, University of Zurich
Manish RAISINGHANI, Target ALS Foundation
Linhao RUAN, Huazhong University of Science and Technology
Neil A. SHNEIDER, Columbia University
Kun SUN, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Yi SUN, Shenzhen University of Advanced Technology
Christine Vande VELDE, University of Montréal
10:30-14:00 |
Registration |
14:00-18:00 |
Short Talks Selected from Abstracts |
08:00-09:00 |
On-site Registration |
09:00-09:15 |
Opening and Introductory Remarks |
09:15-10:00 |
Jeffrey D. ROTHSTEIN, Johns Hopkins School of Medicine TDP-43 Import: A Whole Genome CRISPRi Screen in Human Neurons Reveals Multiple ALS, FTD, and ALS Genes That Work by Altering TDP-43 Import |
10:00-10:30 |
Group Photo & Break |
10:30-10:55 |
Linhao RUAN, Huazhong University of Science and Technology INFINITE: A Screen Platform for Neuronal Nuclear Cytoplasmic Transport Regulators |
10:55-11:20 |
Chunghun LIM, Korea Advanced Institute of Science and Technology Lipid Transfer Proteins at ER Membrane Contact Sites Sustain Lipid Homeostasis and Neuronal Survival in C9ORF72-Associated ALS |
11:20-11:45 |
Sandrine DA CRUZ, VIB-KU Leuven Center for Brain & Disease Research Uncovering Local Mechanisms of Axon/Synapse Maintenance and Demise in ALS/FTD |
11:45-12:10 |
Magdalini POLYMENIDOU, University of Zurich Understanding the Life Cycle of TDP-43: Aggregation Triggers & Toxicity Effectors |
12:10-14:00 |
Lunch & Poster Session |
14:00-14:25 |
Shuying SUN, Johns Hopkins School of Medicine RNA Metabolism Dysfunction in C9ORF72-ALS/FTD |
14:25-14:50 |
Clotilde LAGIER-TOURENNE, Massachusetts General Hospital, Harvard Medical School Disruption of RNA Metabolism in Neurodegenerative Diseases and Emerging Therapeutic Strategies |
14:50-15:15 |
Christine VANDE VELDE, University of Montréal Stress Granules in ALS/FTD Pathogenesis: Friend or Foe? |
15:15-15:40 |
Ge BAI, Zhejiang University Stress Granules and Neurodegeneration |
15:40-16:05 |
Ke ZHANG, Shenzhen Bay Laboratory Novel Ways to Target Stress Granules |
16:05-16:15 |
Break |
16:15-17:00 |
Don W. CLEVELAND, University of California, San Diego |
18:30-20:30 |
Banquet |
08:30-09:00 |
On-site Registration |
09:00-09:45 |
Junying YUAN, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences RIPK1 and Neuroinflammation |
09:45-10:10 |
Yi LIN, Tsinghua University, Peking-Tsinghua Joint Center for Life Sciences Spatiotemporal Control of Biological Processes through Dynamic Phase Separation |
10:10-10:35 |
Yun GE, Shenzhen Bay Laboratory Target Protein Manipulation to Reveal Glycosylation Functions in Condensates |
10:35-10:45 |
Break |
10:45-11:10 |
Xiaojiang LI, Jinan University The Pathogenesis of Cytoplasmic TDP-43 |
11:10-11:35 |
Fen-Biao GAO, University of Massachusetts |
11:35-12:00 |
Justin K. ICHIDA, University of Southern California Identifying New Therapeutic Targets for ALS Using Rare Genetic Variants and CRISPR Technology |
12:00-12:25 |
Ralf JAUCH, The University of Hong Kong Direct Somatic to Neural Stem Cell Conversion to Model and Revert Age-linked Neurological Disorders |
12:25-14:00 |
Lunch & Poster Session |
14:00-14:25 |
Manish RAISINGHANI, Target ALS Foundation Target ALS: Pioneering Collaboration and Innovation to Accelerate ALS Research and Drug Discovery |
14:25-14:50 |
Neil A. SHNEIDER, Columbia University Silencing FUS and Other Rare Genetic Forms of ALS |
14:50-15:15 |
Gong CHEN, Jinan University In Vivo Neural Regeneration and Its Potential in the Treatment of ALS |
15:15-15:40 |
Dongsheng FAN, Peking University Third Hospital Preliminary Study on the Treatment of ALS with rTMS under the Guidance of pBFS |
15:40-15:50 |
Break |
15:50-16:15 |
Aaron D. GITLER, Stanford University ALS Therapeutic Targets |
16:15-16:40 |
Bai LU, Tsinghua University New Strategies to Accelerate ALS Drug Development |
16:40-17:05 |
Yi SUN, Shenzhen University of Advanced Technology |
17:05-17:30 |
Kun SUN, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Translational Advances in SMA Care: From Novel Diagnostics to Prenatal Gene Therapy in Murine Systems |
17:30-18:15 |
C. Frank BENNETT, Ionis Pharmaceuticals, Inc. TBA |
08:30-09:00 |
On-site Registration |
09:00-09:25 |
Xiangjun CHEN, Huashan Hospital, Fudan University Oligogenic ALS Modeling Based on Genotype-phenotype Correlation from the Huashan TRC Study |
09:25-09:50 |
Andrew Stephen LEE, Shenzhen Bay Laboratory, Peking University Shenzhen Graduate School Clinical Translation of Extracellular Vesicle Based Gene Therapy |
09:50-10:15 |
Siqi HONG, Children's Hospital of Chongqing Medical University Diagnosis and Treatment of NMDs in Children: Current Status and Clinical Challenges |
10:15-10:40 |
Yelin CHEN, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences Using ApoE C-terminal Domain to Treat Alzheimer’s Disease |
10:40-10:50 |
Closing Remarks and Poster Award Announcement |
Registration Deadline: October 24, 2025
Please click the Register link at the top of this web page to proceed with the registration process.
Registration will be closed when the number of applications reaches 250.
Registration Fees
*Please upload valid documents for review if you are a student.
Notice
1. When making transfers, please include the following note: ALS + [Your Full Name].
2. Please complete the registration and payment before October 24, 2025. Attendees registering on-site will be provided with only the electronic program.
3. The electronic invoice for the registration fee will be sent to the registered email address within 15 working days after the symposium.
Refund Policy
1. A 2% administrative fee will be charged for all refund transactions.
2. Refund requests submitted after 18:00 (GMT+8) on October 27, 2025 will not be processed.
Abstract Submission Deadline: September 30, 2025
Submission Guidelines:
In the afternoon of October 28, we will have a student/postdoc/junior scientist session featuring short talks selected from submitted abstracts. The symposium will cover the registration and accommodation fees for the short talk presenters.
This conference will feature poster presentation sessions, with awards for outstanding posters. We sincerely invite you to submit your topics and participate in the poster presentation (encouraging the display of the latest research advancements or unpublished research topics).
How to participate: Upload poster information to the registration website.
Poster requirements: If you will present a poster, please print it yourself and bring it to the conference venue. The staff will post it in the designated area.
Poster size: Width 80 cm * Height 120 cm
We do not provide centralized accommodation for this symposium. Participants can arrange their own accommodation by contacting nearby hotels. (If you encounter any difficulty in booking a hotel, please contact us at symposium@smart.org.cn.)
1. EVEN Hotels Shenzhen Guangming Cloud Park, an IHG Hotel
Address: No. 98 Zhenyuan Road, Guangming District, Shenzhen
The hotel is 200 meters (~3-minute walk) from the conference venue.
Contact: Mr. Zhou, Tel: +86-135 0841 8360
2. Holiday Inn Express Shenzhen Guangming Cloud Park, an IHG Hotel
Address: No. 98 Zhenyuan Road, Guangming District, Shenzhen
The hotel is 200 meters (~3-minute walk) from the conference venue.
Contact: Mr. Zhou, Tel: +86-135 0841 8360
3. SYSU Academic Vila, Shenzhen Campus
Address: No.66 Gongchang Road, Guangming District, Shenzhen, Guangdong, China, Guangming District, Shenzhen
The hotel is 2.5 kilometers (~5-minute drive) from the conference venue.
Contact: Mr. Ran, +86-133 3028 2207
4. Guangming CIMC Executive Apartments Hotel
Address: CIMC Executive Apartments Hotel, Qiaoming Road, Fenghuang Street, Guangming District, Shenzhen
The hotel is 7.6 kilometers (~20-minute drive) from the conference venue.
Contact: Mr. Lu, Tel: +86-138 2659 2644
Email: symposium@smart.org.cn
Tel: +86-173 2236 4121