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SMART Symposium on Conquering the Challenges of ALS and Related Neuromuscular Diseases
SMART
Date
October 28-31, 2025
Registration Deadline
October 24, 2025
Venue
Cloud Park International Conference Center, Shenzhen, China
About
Organizers
Confirmed Speakers
Program
Short Talk Presentation
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About
Neuromuscular diseases such as ALS present a global challenge to human health and medicine. Every year, millions suffer from these diseases, and there is still no effective treatment. Emerging efforts from cross-field collaborations led to significant progress toward FDA-approved therapeutics, such as ASO therapies. Our symposium aims to bring together academic, clinical, and industrial experts in ALS and other neuromuscular diseases. Through their brainstorming, we seek to identify ways to conquer the major challenges of these devastating diseases.
Organizers
Xiao-Jiang LI, Jinan University
Ke ZHANG, Shenzhen Bay Laboratory
Aaron GITLER, Stanford University
Shuying SUN, Johns Hopkins University
Confirmed Speakers

Keynote Speakers

(in alphabetic order)

Don CLEVELAND, University of California, San Diego

Jeffrey ROTHSTEIN, Johns Hopkins University

Junying YUAN, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

 

Invited Speakers

(in alphabetic order)

Ge BAI, Zhejiang University

Gong CHEN, Jinan University

Xiangjun CHEN, Huashan Hospital, Fudan University

Yelin CHEN, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

Sandrine DA CRUZ, VIB-KU Leuven Center for Brain & Disease Research

Dongsheng FAN, Peking University Third Hospital

Fen-Biao GAO, University of Massachusetts Chan Medical School

Yun GE, Shenzhen Bay Laboratory

Siqi HONG, Children's Hospital of Chongqing Medical University

Justin ICHIDA, University of Southern California

Ralf JAUCH, The University of Hong Kong

Yichang JIA, Tsinghua University

Andrew LEE, Shenzhen Bay Laboratory, Peking University Shenzhen Graduate School

Chunghun LIM, Korea Advanced Institute of Science and Technology

Yi LIN, Tsinghua University

Bai LU, Tsinghua University

Magdalini POLYMENIDOU, University of Zurich

Manish RAISINGHANI, Target ALS Foundation

Linhao RUAN, Huazhong University of Science and Technology

Neil SHNEIDER, Columbia University

Yi SUN, Shenzhen University of Advanced Technology

Ruilin TIAN, Southern University of Science and Technology

Christine VANDE VELDE, University of Montréal

Keqiang YE, Shenzhen University of Advanced Technology

Xiaorong ZHANG, Chinese Academy of Medical Sciences

Program
October 28
October 29
October 30
October 31
Show All
Day 1
10:30-18:00

10:30-14:00

Registration

14:00-18:00

Short Talks Selected from Abstracts
Day 2
08:00-20:30

08:00-09:00

On-site Registration

09:00-09:15

Opening and Introductory Remarks
Keynote Lecture I
09:15-10:30

09:15-10:00

Jeffrey D. ROTHSTEIN, Johns Hopkins University

TDP-43 Import: A Whole Genome CRISPRi Screen in Human Neurons Reveals Multiple ALS, FTD, and ALS Genes That Work by Altering TDP-43 Import

10:00-10:30

Group Photo & Break
Session I. ALS Cell Biology
10:30-12:10

10:30-10:55

Linhao RUAN, Huazhong University of Science and Technology

INFINITE: A Screen Platform for Neuronal Nuclear Cytoplasmic Transport Regulators

10:55-11:20

Chunghun LIM, Korea Advanced Institute of Science and Technology

ER–Lysosome Contacts Drive Lipotoxicity in C9ORF72-Associated ALS

11:20-11:45

Sandrine DA CRUZ, VIB-KU Leuven Center for Brain & Disease Research

Uncovering Local Mechanisms of Axon/Synapse Maintenance and Demise in ALS/FTD

11:45-12:10

Magdalini POLYMENIDOU, University of Zurich

Understanding the Life Cycle of TDP-43: Aggregation Triggers & Toxicity Effectors
Lunch & Poster Session
12:10-14:00
Session II. RNA Metabolism and Stress Granules
14:00-16:05

14:00-14:25

Shuying SUN, Johns Hopkins University

RNA Metabolism Dysfunction in C9ORF72-ALS/FTD

14:25-14:50

Clotilde LAGIER-TOURENNE, Massachusetts General Hospital, Harvard Medical School

Disruption of RNA Metabolism in Neurodegenerative Diseases and Emerging Therapeutic Strategies

14:50-15:15

Christine VANDE VELDE, University of Montréal

Stress Granules in ALS/FTD Pathogenesis: Friend or Foe?

15:15-15:40

Ge BAI, Zhejiang University

Stress Granules and Neurodegeneration

15:40-16:05

Ke ZHANG, Shenzhen Bay Laboratory

Novel Ways to Target Stress Granules

16:05-16:15

Break
Keynote Lecture II
16:15-17:00

16:15-17:00

Don W. CLEVELAND, University of California, San Diego
TBA
Banquet
18:30-20:30
Day 3
08:30-17:55

08:30-09:00

On-site Registration
Keynote Lecture III
09:00-09:45

09:00-09:45

Junying YUAN, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

RIPK1 and Neuroinflammation
Session III. Liquid-Liquid Phase Separation
09:45-10:35

09:45-10:10

Yi LIN, Tsinghua University

Spatiotemporal Control of Biological Processes Through Dynamic Phase Separation

10:10-10:35

Yun GE, Shenzhen Bay Laboratory

Target Protein Manipulation to Reveal Glycosylation Functions in Condensates

10:35-10:45

Break
Session IV. Animal and iPSC models
10:45-12:25

10:45-11:10

Xiaojiang LI, Jinan University

The Pathogenesis of Cytoplasmic TDP-43

11:10-11:35

Fen-Biao GAO, University of Massachusetts Chan Medical School

Understanding Familial and Sporadic ALS/FTD: Novel Insights from Drosophila and iPSC-Derived Patient Motor Neurons

11:35-12:00

Justin K. ICHIDA, University of Southern California

Identifying New Therapeutic Targets for ALS Using Rare Genetic Variants and CRISPR Technology

12:00-12:25

Ralf JAUCH, The University of Hong Kong

Direct Somatic to Neural Stem Cell Conversion to Model and Revert Age-Linked Neurological Disorders
Lunch & Poster Session
12:25-14:00
Special Lecture
14:00-14:25

14:00-14:25

Manish RAISINGHANI, Target ALS Foundation

Target ALS: Pioneering Collaboration and Innovation to Accelerate ALS Research and Drug Discovery
Session V. ALS Diagnosis and Therapeutics I
14:25-15:40

14:25-14:50

Neil A. SHNEIDER, Columbia University

Silencing FUS and Other Rare Genetic Forms of ALS

14:50-15:15

Gong CHEN, Jinan University

In Vivo Neural Regeneration and Its Potential in the Treatment of ALS

15:15-15:40

Dongsheng FAN, Peking University Third Hospital

Preliminary Study on the Treatment of ALS with rTMS Under the Guidance of pBFS

15:40-15:50

Break
Session VI. ALS Diagnosis and Therapeutics II
15:50-17:55

15:50-16:15

Aaron D. GITLER, Stanford University

ALS Therapeutic Targets

16:15-16:40

Bai LU, Tsinghua University

New Strategies to Accelerate ALS Drug Development

16:40-17:05

Yi SUN, Shenzhen University of Advanced Technology
Autologous Rejuvenated Cell Therapy for ALS

17:05-17:30

Yichang JIA, Tsinghua University

From ALS disease models to ALS gene therapy

17:30-17:55

Kun SUN, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Translational Advances in SMA Care: From Novel Diagnostics to Prenatal Gene Therapy in Murine Systems

 

 
Day 4
08:30-11:15

08:30-09:00

On-site Registration
Session VII. Other Neurodegenerative Diseases
09:00-11:05

09:00-09:25

Keqiang YE, Shenzhen University of Advanced Technology
NMNAT-1 Binds to TDP-43 and Mediates its Copathology in Alzheimer’s Disease

09:25-09:50

Andrew Stephen LEE, Shenzhen Bay Laboratory, Peking University Shenzhen Graduate School

Clinical Translation of Extracellular Vesicle Based Gene Therapy

09:50-10:15

Siqi HONG, Children's Hospital of Chongqing Medical University

Diagnosis and Treatment of NMDs in Children: Current Status and Clinical Challenges

10:15-10:40

Yelin CHEN, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

Using ApoE C-terminal Domain to Treat Alzheimer’s Disease

10:40-11:05

Xiangjun CHEN, Huashan Hospital, Fudan University

Oligogenic ALS Modeling Based on Genotype-Phenotype Correlation from the Huashan TRC Study

11:05-11:15

Closing Remarks and Poster Award Announcement

 

 
Closing & Poster Awards
11:05-11:15

11:05-11:15

Closing Remarks and Poster Award Announcement
Short Talk Presentation

In the afternoon of October 28, we will have a student/postdoc/junior scientist session featuring short talks selected from submitted abstracts. The symposium will cover the registration and accommodation fees for the short talk presenters.

Download

Official Symposium Notice (Chinese)

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