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SMART Symposium on Targeted Protein Degradation: From Basic Science to Therapeutic Application

SMART & SZBL

Date

November 12-14, 2024

Venue

Cloud Park International Conference Center, Guangming District, Shenzhen, China

Email: symposium@smart.org.cn; Hotline: (+86) 173 2236 4121

About

Targeted protein degradation (TPD) stands as a revolutionary technology capable of selectively eliminating specific proteins of interest by leveraging natural cellular processes, including the ubiquitin-proteasome and lysosome pathways. TPD technology holds immense promise for the treatment of diverse diseases, ranging from cancer, neurodegenerative diseases, autoimmune disorders, inflammatory ailments, to viral and bacterial infections. Given its potential to overcome the challenges associated with traditional drug modalities like small molecules and biologics, TPD has garnered significant attention from academia, pharmaceutical industry, and investors world-wide.

The theme of this symposium will be centered on development and application of TPD through chemical and biological innovations, serving not only as a research tool to interrogate and uncover new biology but also as a therapeutic modality to treat human diseases. Join us in lively discussion, networking opportunities with colleagues from diverse backgrounds worldwide, and to discover inspiring presentations and poster sessions at this exciting gathering in Shenzhen, China.

Organizing Committee

Alessio Ciulli, University of Dundee

Peng Chen, Peking University

Nathanael Gray, Standford University

Frank Yan, 3E Bioventures

Nieng Yan, Shenzhen Medical Academy of Research and Translation, Shenzhen Bay Laboratory, Tsinghua University

Speakers

Michael Berlin, Arvinas

Maria-Laura Bolognesi, University of Bologna

Yong Cang, ShanghaiTech University

Giulia Caron, University of Turin

Peng Chen, Peking University

Alessio Ciulli, University of Dundee

Katherine Donovan, Dana-Farber Cancer Institute

Nathanael Gray, Stanford University

Gwenn Hansen, Nurix Therapeutics

Tasuku Ishida, Elix Inc

Katrina Jackson, C4 Therapeutics

Jian Jin, Icahn School of Medicine at Mount Sinai

Manfred Koegl, Boehringer Ingelheim RCV

Wei Lin, Revolution Medicines

Boxun Lu, Fudan University

Hannah Maple, Bio-Techne

Behnam Nabet, Fred Hutchinson Cancer Center

Yu Rao, Tsinghua University

Joachim Rudolph, Genentech

Mathew Sowa, C4 Therapeutics

Weiping Tang, University of Wisconsin-Madison

Andrea Testa, Trimtech Therapeutics

Vesna Vetma, University of Dundee

Shaomeng Wang, University of Michigan Comprehensive Cancer Center

Peng Wu, Scripps Research

Yue Xiong, Cullgen

Tinghu Zhang, Stanford University

Guangrong Zheng, University of Florida

Ning Zheng, University of Washington

Program

Day 1 (November 11)
16:00 - 20:00	Check-in and registration

Day 2 (November 12)
08:00 - 09:00	Registration
09:00 - 09:05	Opening remarks
Session 1: Proteolysis targeting chimera (PROTAC) Chair: Long Gui
09:05 - 09:35	Giulia Caron, University of Turin Emerging strategies to design oral bioavailable PROTAC drugs
09:35 - 10:05	Vesna Vetma, University of Dundee Targeting cancer with small molecule panKRAS degraders
10:05 - 10:35	Shaomeng Wang, University of Michigan Targeting “undruggable” proteins using the PROTAC technology for new therapeutics
10:35 - 11:05	Break & Group photo
11:05 - 11:35	Maria-Laura Bolognesi, University of Bologna Opportunities and challenges in the discovery of PROTACS for treating parasitic diseases
11:35 - 12:05	Alessio Ciulli, University of Dundee New insights and twists on PROTAC and molecular glue degraders design and mechanism
12:05 - 12:35	Jian Jin, Icahn School of Medicine at Mount Sinai New approaches to target undruggable proteins
12:35 - 14:00	Lunch break
Session 2: Molecular glue and induced proximity Chair: Yunnan Hou
14:00 - 14:30	Tasuku Ishida, Elix, Inc. Intramolecular bivalent molecular glue: a novel mechanism for targeted protein degradation
14:30 - 15:00	Nathanael Gray, Stanford University Induced proximity from degraders to transcriptional activators
15:00 - 15:30	Andrea Testa, Trimtech Therapeutics Inducing proximity "two ways": a differentiated TPD approach to selectively degrade protein aggregates
15:30 - 16:00	Ting Han, National Institute of Biological Sciences, Beijing Selective degradation of multimeric proteins by molecular glue and PROTAC degraders
16:00 - 16:30	Yong Cang, ShanghaiTech University Targeting the undruggable proteome with molecular glue degraders
16:30 - 18:00	Poster session

Day 3 (November 13)

Session 3: Targeted protein degradation (TPD) in drug discovery and development Chair: Xiaoyu Tang
09:00 - 09:30	Manfred Koegl, Boehringer Ingelheim RCV Confounding factors in the degradation of short-lived proteins
09:30 - 10:00	Joachim Rudolph, Genentech Discovery of new monovalent degraders of SMARCA2/A4
10:00 - 10:30	Guangrong Zheng, University of Florida Discovery of Bcl-xL and Bcl-2 selective degraders for clinical translation
10:30 - 11:00	Break
11:00 - 11:30	Michael Berlin, Arvinas Recent progress in the neuroscience drug discovery programs using PROTAC^® technology
11:30 - 12:00	Wei Lin, Revolution Medicines Targeting the active state of RAS using the tricomplex platform
12:00 - 12:30	Kate Jackson, C4 Therapeutics, Inc. The discovery and characterization of a selective and orally bioavailable bromodomain-containing protein 9 (BRD9) degrader
12:30 - 14:00	Lunch
14:00 - 14:30	Gwenn Hansen, Nurix Therapeutics, Inc. Discovery of a pan-mutant BRAF degrader for the treatment of primary and inhibitor-resistant solid tumors
14:30 - 15:00	Mathew Sowa, C4 Therapeutics, Inc. CFT1946 is a potent, selective BiDACTM degrader of BRAF V600 mutant protein with superior efficacy to approved inhibitors in preclinical models and shows early evidence of clinical anti-tumor activity in BRAF V600 mutant driven cancers
15:00 - 16:00	Break & Poster session
Session 4: Membrane protein degradation (MPD) Chair: Yun Ge
16:00 - 16:30	Peng Chen, Peking University Targeted Protein Degradation in the transmembrane and extracellular space
16:30 - 17:00	Peng Wu, The Scripps Research Institute Degradation of Slglec-7 and -9 to reprogram tumor microenvironment for cancer immunotherapy
17:00 - 17:30	Weiping Tang, University of Wisconsin-Madison Enabling platforms to accelerate the development of degraders for intra- and extracellular proteins
17:30 - 18:00	Boxun Lu, Fudan University A potential new degrader technology targeting membrane proteins
18:00 - 20:00	Banquet & Poster award
20:00 - 22:00	Cocktail party for all participants

Day 4 (November 14)

Session 5: Structural biology, proteomics, and new modalities Chairs: Xin Li, Huadong Li
09:00 - 09:30	Behnam Nabet, Fred Hutchinson Cancer Center Strategies to chemically control protein stability and activity
09:30 - 10:00	Ning Zheng, University of Washington Converging mechanism of a molecular glue degrader and cancer mutations
10:00 - 10:30	Katherine Donovan, Dana-Farber Cancer Institute Unveiling the hidden interactome of CRBN molecular glues with chemoproteomics
10:30 - 11:00	Break
11:00 - 11:30	Yu Rao, Tsinghua University Targeted Protein Degradation technology and applications
11:30 - 12:00	Tinghu Zhang, Stanford University Covalent Glue for protein degradation
12:00 - 12:30	Yue Xiong, Cullgen Targeting TRK protein degradation for cancer therapy and pain management
12:30 - 14:00	Lunch
14:00 - 14:30	Hannah Maple, Bio-Techne Next-generation covalent BromoTag as a novel tool for intracellular protein labeling
14:30 - 15:00	Weihong Tan, Hangzhou Institute of Medicine Chinese Academy of Sciences Aptomics lead to multiomics: a new frontier in molecular medicine
15:00 - 15:05	Closing remarks

Registration

Registration has been closed. We look forward to your participation in our future symposia!

Please click the Register link on top of this web page to proceed the registration process. Please finish your registration information before November 9, 2024 via our website.

Registration Fee

* The registration fee includes lunch from November 12 to November 14, and dinner on November 13.

* Please upload valid documents for review if you are a student.

Notice：

1. When making the transfer, kindly include the following note: [Symposium Name] + [Your Full Name].

2. Please complete the registration and payment before November 9, 2024. Attendees registering on-site will be provided with electronic program only.

3. The electronic invoice for the registration fee will be sent to the registered email address within 15 working days after the symposium.

4. Attendees registering on-site will be provided with electronic program book only.

Poster Session

Registration has been closed. We look forward to your participation in our future symposia!

This conference will feature a poster presentation session, with an award for outstanding posters. We sincerely invite you to submit your topics and participate in the poster presentation (encouraging the display of the latest research advancements or unpublished research topics).

How to participate: Upload poster information to the registration website.

Poster requirements: If you participate in the poster presentation, please print the poster yourself and bring it to the conference venue to be posted in the designated area by the staff.

Poster size: Width 80 cm*Height 120cm

Deadline: November 9, 2024

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